Antibiotic-associated diarrhea and colitis have climbed since the 1980’s. The CDC estimates over 2 million illnesses annually due to antibiotic resistance. Many infections are attributed to C. difficile, a pathogen that colonizes the gastrointestinal tract. C. difficile infections cause diarrhea and colitis and contributed to 29,000 deaths in the U.S. in 2015, primarily in elderly populations.
This is how VBX-100 is targeted to work in the GI tract. In addition to avoiding psychoactivity, it also avoids the adverse effects of current immunosuppressants.
Vitality has filed for intellectual property protection on more than 100 different glycoside prodrugs, including VBX-100. “VBX-100 is our lead program,” said Robert Brooke, Vitality’s CEO.
Dr. Brandon Zipp, Vitality’s Director of R&D, said that “Our studies show cannabinoids may be useful for both addressing the inflammatory state of the colon, as well as confronting the microbial dysbiosis at the root of the problem. This represents a new possible mechanism for cannabinoids, yet is very much in-line with the current scientific understanding that cannabinoids can play a prominent role in promoting intestinal homeostasis and long-term healing.”